ea0014s10.3 | GH and prolactin at their targets | ECE2007
Tabruyn Sébastien
, Sabatel Céline
, Nguyen Ngoc-Quynh-Nhu
, Verhaeghe Catherine
, Castermans Karolien
, Malvaux Ludovic
, Griffioen Arjan
, Martial Joseph
, Struman Ingrid
The 16-kDa N-terminal fragment of human prolactin (16K hPRL) is a potent angiostatic factor described to prevent tumor growth in mouse models. Using microarray experiments, we have dissected how the endothelial-cell genome responds to 16K hPRL treatment. Of the 23.000 transcripts present on the chips, 210 are regulated by 16K hPRL. Bio-informatic analysis and experiments performed on endothelial cells with various chemical inhibitors clearly suggest that NF-κB is crucial ...